Mike is currently Chief Scientific Officer at DiaCarta, Inc. where he manages the company’s scientific and strategic direction in molecular diagnostics for oncology and infectious disease personalized diagnostics markets, most notably the development of branched DNA (bDNA) signal amplification and a novel somatic gene mutation Real-Time PCR based assay technology called QClampTM for applications in the diagnosis of cancer and infectious diseases and the rapid detection of cancer 'driver' and drug resistance genetic variations. Mike was previously a Founder of Odyssey Thera Inc., a privately held company that commercialized a proprietary fluorescent live cell-based assay and diagnostic imaging technology for the application in target validation and drug discovery. Mike was the Director of New Technology at Roche Diagnostics (Roche acquired Boehringer Mannheim Corporation in May 1997 for $11B). Prior to the acquisition by Roche, he was Director of New Technology at Boehringer Mannheim. He was also the Director of New Technology at Microgenics Corporation, in Concord, California. He was a pioneer and lead scientist and inventor of the electrochemiluminescence (ECL) assay technology and also developed catalytic antibodies at IGEN, Inc. The ECL technology is the basis of Roche Diagnostics automated ‘in-vitro’ diagnostics immunoassay platform: ‘ElecSys’. Mike has held several other R & D senior management positions at Integrated Genetics Inc., Medisense and Celltech PLC, in the UK. Mike has published many research papers in leading scientific journals and holds over 30 patents and patent-pending applications. He received his Ph.D. in medicinal organic chemistry from Loughborough University, Loughborough, UK and Ph.D. from the University of Nottingham, Nottingham, UK.
Translational genomics and Precision diagnostics to support disease diagnosis and therapy
Oscar is the Head of Flow Cytometry Unit at Centre for Genomic Regulation and Pompeu Fabra University in Barcelona, Spain, since 2001, where coordinates the assistance, supervision and training of one of the most advanced flow cytometry platforms in Europe. The Unit assists, supervise and advise more than 300 users from around 120 research groups in Spain and Europe. He supports the use of most flow cytometry applications, develops and implements new ones under scientific community needs. He received his Ph.D in Biochemistry from Autonomous University of Barcelona, Spain and he started to develop advanced Flow Cytometry applications during his first post-doc, at Cancer Research Institute (IRO) in Barcelona, Spain. Oscar has published relevant research papers in leading scientific journals, developing advanced Flow Cytometry methodologies and specific cell sorting. One of those was a relevant new methodological approach for hematopoietic stem cells detection and enumeration by Flow Cytometry with clinical implications. In 2012 he implemented flow karyotyping for chromosomes sorting and, currently is the unique Flow Cytometry Unit in Europe providing this special application as a service. Additionally, he recently combined this application with subsequent chromosome sequencing without amplification by using Oxford Nanopore technologies as a new methodology to assemble structurally very complex chromosomes. Currently, Oscar is focused in develop strategies to detect and isolate nanoparticles by Flow Cytometry. Recently, he has developed an approach for Single-Virus sorting for subsequent single-virus genomics. This methodology allows the possibility to explore the diversity of viruses in different ecosystems and to elucidate the global microbiome, in special, the global virosphere. He has also developed a new approach to identify and isolate Extracellular Vesicles (smaller than 100nm) by Flow Cytometry, to study cell communication and, based on Extracellular Vesicles’ cargo transfer, looking for biomarkers related with diseases. His Unit is becoming a reference site for advanced Flow Cytometry applications and sorting at the single-particle level. Oscar also participates, as membership, in alliances of excellence, as Core4life, an ”Excellence Alliance of Life Science Core Facilities in Europe”.
Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis
Marcel is an accomplished, versatile and passionate Business Executive; driving product innovation in a global science-based market leader, and shaping/executing a successful growth strategy of a disruptive, entrepreneurial SME. Commercially agile, boasting an outstanding track record of propelling business operations forward via organic and acquisition activities; collaborating at board level with multiple shareholders, customers, and external investors to enable businesses to reach their full potential on a truly global scale. Experience in Chemical Industry, Clean-tech, Renewables and Polymers & Materials, with the proven ability to inspire performance and deliver competitive advantage. Marcel van Berkel studied Chemistry and Business Administration in Utrecht, the Netherlands. He worked for more than 30 years for corporate companies like Solvay and DSM. Marcel left DSM to expedite the growth of a start-up in the bio-based chemicals industry. After completing this successfully, he started at the Biobased Delta as VP-Sugar Delta. Sugar Delta is the area in South-West Netherlands were annually 3m tons of sugar is produced and traded. With this unique selling point, Marcel van Berkel is attracting new business activities to this area.
Magnus S. Magnusson, PhD, Emeritus Research Professor, founder and director of the Human Behavior Laboratory (hbl.hi.is), University of Iceland. Author of the T-pattern, T-string and T-system model and the corresponding detection algorithms and software THEMETM (PatternVision.com), initially focusing on real-time organization of behavior. Co-directed DNA analysis. Numerous papers, talks and keynotes in ethology, neuroscience, mathematics, religion, proteomics, mass spectrometry, A.I., robotics and nanoscience. Deputy Director 1983-1988 in Museum of Mankind, National Museum of Natural History, Paris. Repeatedly invited Professor at the University of Paris, V, VIII and XIII in psychology and the biology of behavior. Now works in formal collaboration between 32 European and American universities initiated 1995 at the University Rene Descartes of Paris V, Sorbonne, based on “Magnusson’s analytical model”.
Giant T-patterned purely informational strings and self-similarity from the RNA world to human mass-societies
Desineni “Subbaram” Naidu received MTech and PhD degrees in Electrical Engineering (with specialization in Control Systems Engineering), from Indian Institute of Technology (IIT), Kharagpur. Dr. Naidu taught, visited and/or conducted research at IIT; as National Research Council (NRC) Senior Research Associate at Guidance and Control Division at NASA Langley Research Center, Hampton, VA; Old Domain University, Norfolk, VA; as Professor, Associate Dean and Director, School of Engineering at Idaho State University and Measurement and Control Engineering Research Center, Pocatello, Idaho; as National Research Council (NRC) Senior Research Associate at Center of Excellence in Advanced Flight Research at United States (US) Air Force Research Laboratory, Wright Patterson Air Force Base (WPAFB), Ohio; as Visiting Research Fellow at Center of Excellence for Ships and Ocean Structures at Norwegian University of Science and Technology, Trondheim, Norway; as Academic Guest at Measurement and Control Laboratory at Swiss Federal Institute of Technology, Zurich, Switzerland; as Visiting Professor at Nantong University, Nanton, China; Visiting Research Professor at the University of Western Australia in Perth, Center for Industrial and Applied Mathematics at the University of South Australia in Adelaide; Jiangsu College of Information Technology, Jiangsu, China; as Visiting Professor at the Center for Applied and Interdisciplinary Mathematics at East China Normal University, Shanghai, China; as Visiting Professor at the Institute of Systems Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China; Shanghai Jiao-Tong University, Shanghai, China and as Satish Dhawan Endowed Visiting Professor at Indian Inst. of Science (IISc), Bengaluru, India. Since August 2014, Professor Naidu has been with University of Minnesota Duluth as Minnesota Power Jack Rowe Endowed Chair. Professor Naidu received twice the Senior National Research Council (NRC) Associateship award from the US National Academy of Sciences (NAS), and is an elected (Life) Fellow of the Institute of Electrical and Electronic Engineers (IEEE) and an elected Fellow of the World Innovation Foundation, UK. Professor Naidu has over 200 journal and conference publications including 8 books. He has been on the editorial boards of several journals including the IEEE Transactions on Automatic Control and Optimal Control: Applications and Methods (Wiley). More details at http://www.d.umn.edu/~dsnaidu/
Molecular Modelling,Biosensors, Biomarkers